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Ruptured Ectopic Pregnancy

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Acute Abdomen During Pregnancy

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Abstract

Ectopic pregnancy is one of the most common nonsurgical abdominal conditions during pregnancy. Unfortunately, most of these presentations are during early pregnancy when the conceptus is not developed for independent life and is also not “viable.” Preoperative and early diagnosis is common due to the specific clinical presentation and the routine use of βHCG for women of reproductive age presenting with pain in the lower abdomen. Both conservative and operative interventions are available and successful depending on the fetal status and severity of bleeding. The biggest diagnostic and therapeutic dilemmas arise in patients with heterotopic or advanced abdominal pregnancies. The clinician should always look for intrauterine pregnancy preoperatively, even when ectopic pregnancy is confirmed. Advanced abdominal pregnancy poses a real intraoperative problem due to adherence of the placenta to surrounding organs and tissues, and insisting on its complete removal can cause significant and sometimes unstoppable bleeding. Hepatic and splenic pregnancies are prone to severe bleeding due to the pronounced vascularity of these organs.

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References

  1. CDC. Ectopic pregnancy surveillance in the United States, 1970–1987. Morb Mortal Wkly Rep. 1990;39:9–17.

    Google Scholar 

  2. CDC. Ectopic pregnancy – United States, 1990–1992. Morb Mortal Wkly Rep. 1995;44:46–8.

    Google Scholar 

  3. Luciano G, Solima E, et al. Ectopic pregnancy: from surgical to medical management. Ann N Y Acad Sci. 2001;943:235–54.

    CAS  PubMed  Google Scholar 

  4. Mann LM, Kreisel K, Llata E, Hong J, Torrone EA. Trends in ectopic pregnancy diagnoses in United States emergency departments, 2006–2013. Matern Child Health J. 2020;24:213–21.

    PubMed  PubMed Central  Google Scholar 

  5. Murray H, Bardell T, Tulandi T, et al. Diagnosis and treatment of ectopic pregnancy. CMAJ. 2005;173:905–12.

    PubMed  PubMed Central  Google Scholar 

  6. Cagnacci S, Volpe A, et al. Rhythmic variation in the rate of ectopic pregnancy throughout the year. J Obstet Gynaecol. 1999;180:1067–71.

    CAS  Google Scholar 

  7. Chelli C, Boudaya F, Guelmami K, et al. Grossesse ovarienne, à propos de trois cas. Tunis Med. 2009;87:797–800.

    PubMed  Google Scholar 

  8. Refaat B, Dalton E, Ledger WL. Ectopic pregnancy secondary to in vitro fertilisation-embryo transfer: pathogenic mechanisms and management strategies. Reprod Biol Endocrinol. 2015;13(1):30.

    PubMed  PubMed Central  Google Scholar 

  9. Bouyer J, Fernandez H, et al. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod. 2002;17:3224–30.

    CAS  PubMed  Google Scholar 

  10. Shaw SK, Critchley HO, Horne AW, et al. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update. 2010;16:432–44.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Ectopic Pregnancy. WHEC Practice Bulletin and Clinical Management Guidelines for healthcare providers. http://www.womenshealthsection.com/content/print.php3?title=obs024&cat=2&lng=english

  12. Ceci O, Caradonna F, Loizzi P, Lobascio A, Bratta FG, Ferreri R, et al. Ultrasound diagnosis of heterotopic pregnancy with viable fetuses. Eur J Obstet Gynecol Reprod Biol. 1993;52(3):229–31.

    CAS  PubMed  Google Scholar 

  13. Glassner MJ, Aron E, Eskin BA. Ovulation induction with clomiphene and the rise in heterotopic pregnancies. A report of two cases. J Reprod Med. 1990;35(2):175–8.

    Google Scholar 

  14. Selo-Ojeme DO, GoodFellow CF. Simultaneous intrauterine and ovarian pregnancy following treatment with clomiphene citrate. Arch Gynecol Obstet. 2002;266(4):232–4.

    CAS  PubMed  Google Scholar 

  15. Hirose T, Wakuda K, et al. Intrauterine and ovary pregnancy: a case report. Asia Oceania J Obstet Gynaecol. 1994;20:25–9.

    CAS  PubMed  Google Scholar 

  16. Peleq I, Neuman-Levin M, et al. Early diagnosis and successful non surgical treatment of viable combined intrauterine and cervical pregnancy. Fertil Steril. 1994;62:405–8.

    Google Scholar 

  17. Alsunaidi M. An unexpected spontaneous triplet heterotopic pregnancy. Saudi Med J. 2005;26:136–8.

    PubMed  Google Scholar 

  18. Sherer JJ, Sanko SR, et al. Heterotopic quadruplet gestation with laparoscopic resection of ruptured interstitial pregnancy and subsequent successful outcome of triplets. Am J Obstet Gynecol. 1995;172:216–7.

    CAS  PubMed  Google Scholar 

  19. Kemmann S, Garcia A, et al. Can we predict patients at risk for persistent ectopic pregnancy after laparoscopic salpingotomy? J Am Assoc Gynecol Laparosc. 1994;1:122–6.

    CAS  PubMed  Google Scholar 

  20. Poppe WA, Vandenbussche N. Postoperative day 3 serum human chorionic gonadotropin decline as a predictor of persistent ectopic pregnancy after linear salpingotomy. Eur J Obstet Gynecol Reprod Biol. 2001;99(2):249–52.

    Google Scholar 

  21. Eastman N. Williams obstetrics. New York, NY: Appleton, Century, Crofts; 1950.

    Google Scholar 

  22. Beacham WD. Progress in gynecology. New York, NY: Grune & Stratton; 1950. p. 370–1.

    Google Scholar 

  23. Eden T. On the importance of pain and haemorrhage as symptoms of extrauterine gestation. BMJ. 1909;1:940–3.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Raziel A, Schachter M, Mordechai E, Friedler S, Panski M, Ron-El R. Ovarian pregnancy - a 12-year experience of 19 cases in one institution. Eur J Obstet Gynecol Reprod Biol. 2004;114(1):92–6.

    PubMed  Google Scholar 

  25. Harris HV, et al. Cullen’s sign revisited. Am J Med. 2008;121:682–3.

    PubMed  Google Scholar 

  26. Cullen T. A new sign in ruptured extrauterine pregnancy. Am J Obstet. 1918;78:457.

    Google Scholar 

  27. Meyers MA, Feldberg MAM, Oliphant M. Grey Turner’s sign and Cullen’s sign in acute pancreatitis. Gastrointest Radiol. 1989;14(1):31–7.

    CAS  PubMed  Google Scholar 

  28. Mabin M, et al. Cullen’s sign, a feature of liver disease. BMJ. 1974;1:493–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Dart RG, Kaplan B, Varaklis K. Predictive value of history and physical examination in patients with suspected ectopic pregnancy. Ann Emerg Med. 1999;33(3):283–90.

    CAS  PubMed  Google Scholar 

  30. Tilden R, et al. Ectopic pregnancy: avoiding missed diagnosis and reducing morbidity. Emerg Med Rep. 1996;17:199–206.

    Google Scholar 

  31. Bailey RK, Miller SF, Jones LM, et al. Acute appendicitis during pregnancy. Am Surg. 1986;52:218–21.

    CAS  PubMed  Google Scholar 

  32. Weckstein L. Current perspective on ectopic pregnancy. Obstet Gynecol Surv. 1985;40:259–72.

    CAS  PubMed  Google Scholar 

  33. Raymond P. The ubiquitous umbilicus: what it can reveal about intra-abdominal disease. Postgrad Med. 1990;87:175–81.

    CAS  PubMed  Google Scholar 

  34. Silvestre R, Betlloch I, et al. Cullen’s sign secondary to intra-abdominal non-Hodgkin’s lymphoma. Am J Gastroenterol. 1996;91:1040–1.

    CAS  PubMed  Google Scholar 

  35. Lozeau AM, Potter B. Diagnosis and management of ectopic pregnancy. Am Fam Physician. 2005;72(9):1707–14.

    Google Scholar 

  36. Bree RL, Edwards M, Bohm-Velez M, Beyler S, Roberts J, Mendelson EB. Transvaginal sonography in the evaluation of normal early pregnancy: correlation with HCG level. Am J Roentgenol. 1989;153(1):75–9.

    CAS  Google Scholar 

  37. Snyder HS. Lack of a tachycardic response to hypotension with ruptured ectopic pregnancy. Am J Emerg Med. 1990;8(1):23–6.

    CAS  PubMed  Google Scholar 

  38. Aaryya DJ, et al. Ruptured ectopic pregnancy presenting as hyperglycemia. Int J Clin Pract. 2000;54:409–10.

    Google Scholar 

  39. Verhaegen J, Gallos ID, van Mello NM, Abdel-Aziz M, Takwoingi Y, Harb H, et al. Accuracy of single progesterone test to predict early pregnancy outcome in women with pain or bleeding: meta-analysis of cohort studies. BMJ. 2012;345(4):e6077.

    Google Scholar 

  40. Nahar MN, Quddus MA, Sattar A, Shirin M, Khatun A, Ahmed R, et al. Comparison of transvaginal and transabdominal ultrasonography in the diagnosis of ectopic pregnancy. Bangladesh Med Res Counc Bull. 2013;39(3):104–8.

    CAS  PubMed  Google Scholar 

  41. Elson CJ, Salim R, Potdar N, Chetty M, Ross JA, Kirk EJ. Diagnosis and management of ectopic pregnancy: green-top guideline No. 21. BJOG. 2016;123:e15–55.

    Google Scholar 

  42. Ghi A, Marconi R, et al. Three-dimensional sonographic diagnosis of ovarian pregnancy. Ultrasound Obstet Gynecol. 2005;26:102–4.

    CAS  PubMed  Google Scholar 

  43. Holland MG, Bienstock JL. Recurrent ectopic pregnancy in a cesarean scar. Obstet Gynecol. 2008;111(2 Pt 2):541–5.

    PubMed  Google Scholar 

  44. Sohail S. Haemorrhagic corpus luteum mimicking heterotopic pregnancy. J Coll Physicians Surg Pak. 2005;15:180–1.

    PubMed  Google Scholar 

  45. Michalak M, Zurada A, Biernacki M, Zygmunt K. Ruptured ectopic pregnancy diagnosed with computed tomography. Pol J Radiol. 2010;75(4):44–6.

    PubMed  PubMed Central  Google Scholar 

  46. Okamoto Y, Tanaka YO, Nishida M, Tsunoda H, Yoshikawa H, Itai Y. MR imaging of the uterine cervix: imaging-pathologic correlation. Radiographics. 2003;23(2):425–45; quiz 534–5.

    PubMed  Google Scholar 

  47. Singh S. Diagnosis and management of cervical ectopic pregnancy. J Hum Reprod Sci. 2013;6(4):273–6.

    PubMed  PubMed Central  Google Scholar 

  48. Vermesh M, Graczykowski JW, Sauer MV. Reevaluation of the role of culdocentesis in the management of ectopic pregnancy. Am J Obstet Gynecol. 1990;162(2):411–3.

    CAS  PubMed  Google Scholar 

  49. Li W, Wang G, Lin T, Sun W. Misdiagnosis of bilateral tubal pregnancy: a case report. J Med Case Rep. 2014;8(1):342.

    Google Scholar 

  50. Gebeh AA, Joseph O, Banerjee A, et al. Laparoscopic surgery for ovarian pregnancy using diathermy hook with conservation of ovary: a case report and literature review. J Clin Med. 2013;2:214–9.

    PubMed  PubMed Central  Google Scholar 

  51. Hallatt J. Primary ovarian pregnancy: a report of twenty-five cases. Am J Obstet Gynecol. 1982;143:55–60.

    CAS  PubMed  Google Scholar 

  52. Layden E, Madhra M. Ectopic pregnancy. Obstet Gynaecol Reprod Med. 2020;30(7):205–12.

    Google Scholar 

  53. Harbert W. A case of extra uterine pregnancy. West J Med Surg. 1849;3:110.

    Google Scholar 

  54. Tait R. Five cases of extrauterine pregnancy operated upon at the time of rupture. BMJ. 1884;1:1250–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Tait R. Lectures on ectopic pregnancy and pelvic haematocele. Birmingham: The “Journal” Printing Works; 1888.

    Google Scholar 

  56. Rongy A. The treatment of ectopic gestation based on a study of 100 cases, with a report of twelve cases of repeated ectopic pregnancies. Trans Am Assoc Obstet Gynecol. 1918;30:277–8.

    Google Scholar 

  57. Hartman H, editor. Gynecological operation including nonoperative treatment and minor gynecology. Philadelphia, PA: P. Blakiston’s Son & Co; 1913. p. 460–4.

    Google Scholar 

  58. Hope R. The differential diagnosis of ectopic pregnancy by peritoneoscopy. Surg Gynecol Obstet. 1937;64:229–34.

    Google Scholar 

  59. Hajenius S, Mol BW, et al. Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. Lancet. 1997;350:774–9.

    CAS  PubMed  Google Scholar 

  60. Hill JC, Levy G, et al. Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location. Fertil Steril. 2014;101:413–9.

    CAS  PubMed  Google Scholar 

  61. Birge O, Erkan MM, Ozbey EG, Arslan D. Medical management of an ovarian ectopic pregnancy: a case report. J Med Case Rep. 2015;9:1.

    Google Scholar 

  62. DeCherney AH, Jones EE. Ectopic pregnancy. Clin Obstet Gynecol. 1985;28(2):365–74.

    CAS  PubMed  Google Scholar 

  63. Nelson LM, Margara RA, Winston RM. Primary and secondary closure of ampullary salpingotomy compared in the rabbit. Fertil Steril. 1986;45(2):292–5.

    Google Scholar 

  64. Mol F, van Mello NM, Strandell A, Strandell K, Jurkovic D, Ross J, et al. Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial. Lancet. 2014;383(9927):1483–9.

    PubMed  Google Scholar 

  65. Vancaillie TG. Salpingectomy. Obstet Gynecol Clin N Am. 1991;18(1):111–22.

    CAS  Google Scholar 

  66. Ory E, Herrmann R, et al. Fertility after ectopic pregnancy. Fertil Steril. 1993;60:231–5.

    CAS  PubMed  Google Scholar 

  67. Samuelsson A, et al. Laparoscopy in suspected ectopic pregnancy. Acta Obstet Gynecol Scand. 1972;51:31–5.

    CAS  PubMed  Google Scholar 

  68. Shapiro DH, et al. Excision of an ectopic pregnancy through the laparoscope. Am J Obstet Gynecol. 1973;117:290–1.

    CAS  PubMed  Google Scholar 

  69. Bruhat MA, Manhes H, Mage G, Pouly JL. Treatment of ectopic pregnancy by means of laparoscopy. Fertil Steril. 1980;33(4):411–4.

    Google Scholar 

  70. DeCherney AH, Maheaux R, Naftolin F. Salpingostomy for ectopic pregnancy in the sole patent oviduct: reproductive outcome. Fertil Steril. 1982;37(5):619–22.

    Google Scholar 

  71. Ling TG, et al. Update on the management of ectopic pregnancy. Adv Obstet Gynecol. 1994;1:57.

    Google Scholar 

  72. Hajenius PJ, Mol F, Mol BWJ, Bossuyt PMM, Ankum WM, van der Veen F. Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev. 2007:CD000324.

    Google Scholar 

  73. Mol BW, Matthijsse HC, Tinga DJ, Huynh T, Hajenius PJ, Ankum WM, et al. Fertility after conservative and radical surgery for tubal pregnancy. Hum Reprod. 1998;13(7):1804–9.

    Google Scholar 

  74. Bouyer J, Job-Spira N, Pouly JL, Coste J, Germain E, Fernandez H. Fertility following radical, conservative-surgical or medical treatment for tubal pregnancy: a population-based study. BJOG. 2000;107(6):714–21.

    CAS  PubMed  Google Scholar 

  75. Leeman LM, Wendland CL. Cervical ectopic pregnancy. Diagnosis with endovaginal ultrasound examination and successful treatment with methotrexate. Arch Fam Med. 2000;9(1):72–7.

    CAS  PubMed  Google Scholar 

  76. Johnson W. A study of two hundred forty-five cases of ruptured ectopic pregnancy. Am J Obstet Gynecol. 1952;64:1102–10.

    CAS  PubMed  Google Scholar 

  77. Creanga CK, Bish CL, et al. Trends in ectopic pregnancy mortality in the United States: 1980–2007. Obstet Gynecol. 2011;117:837–43.

    PubMed  Google Scholar 

  78. Nahum GG. Rudimentary uterine horn pregnancy. The 20th-century worldwide experience of 588 cases. J Reprod Med. 2002;47(2):151–63.

    Google Scholar 

  79. Jayasinghe Y, Rane A, Stalewski H, Grover S. The presentation and early diagnosis of the rudimentary uterine horn. Obstet Gynecol. 2005;105(6):1456–67.

    Google Scholar 

  80. O’Leary JA, et al. Rudimentary horn pregnancy. Obstet Gynecol. 1963;22:371–5.

    PubMed  Google Scholar 

  81. Whitehouse B. Rupture of pregnant rudimentary horn of bicornuate uterus. Proc R Soc Med. 1912;5:121–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  82. Mauriceau F. Traité des maladaies des femmes grosses, et de celles qui sont accouchées, vol. 1. 6th ed. Paris: Compaigne des Libraries Paris; 1721. 86 p.

    Google Scholar 

  83. Johansen K. Pregnancy in a rudimentary horn. Obstet Gynecol. 1983;61:565–7.

    Google Scholar 

  84. Lai CH, Hou WC, et al. Pregnancy in a noncommunicating rudimentary horn of a unicornuate uterus: Prerupture diagnosis and management. Taiwan J Obstet Gynecol. 2016;55:604–6.

    Google Scholar 

  85. Wang Y, Yu F, Zeng LQ. Ectopic pregnancy in uncommon implantation sites: intramural pregnancy and rudimentary horn pregnancy. Case Rep Obstet Gynecol. 2015;2015:1–5.

    Google Scholar 

  86. Heinonen PK, Aro P. Rupture of pregnant noncommunicating uterine horn with fetal salvage. Eur J Obstet Gynecol Reprod Biol. 1988;27(3):261–5.

    CAS  PubMed  Google Scholar 

  87. Jain N, Puri M, Trivedi S, et al. A rare case of intact rudimentary horn pregnancy presenting as hemoperitoneum. J Hum Reprod Sci. 2010;3:113–5.

    PubMed  PubMed Central  Google Scholar 

  88. Rolen AJ, Aemmens JP, et al. Rudimentary uterine horn: obstetric and gynecologic complications. Obstet Gynecol. 1966;68:224–30.

    Google Scholar 

  89. Pal K, Majumdar S, Mukhopadhyay S. Rupture of rudimentary uterine horn pregnancy at 37 weeks gestation with fetal survival. Arch Gynecol Obstet. 2006;274(5):325–6.

    PubMed  Google Scholar 

  90. Gagnon F, Williams K, et al. Twin pregnancy with one fetus in a rudimentary horn: a case report of a surviving twin. BJOG. 1998;105:1326–8.

    CAS  Google Scholar 

  91. Oral B, Güney M, Özsoy M, Sönal S. Placenta accreta associated with a ruptured pregnant rudimentary uterine horn: case report and review of the literature. Arch Gynecol Obstet. 2001;265(2):100–2.

    CAS  PubMed  Google Scholar 

  92. Nahum G. Uterine anomalies, induction of labor, and uterine rupture. Obstet Gynecol. 2005;106:1150–2.

    PubMed  Google Scholar 

  93. Shaw WF, Lockyer C. Harold Beckwith Whitehouse. BJOG. 1943;50(5):372–8.

    Google Scholar 

  94. Hamai T, Iwasaki M, et al. A case of pregnancy in a woman with cloacal dysgenesis and a rudimentary uterine horn. Hum Reprod. 1997;12:1103–5.

    CAS  PubMed  Google Scholar 

  95. Johansen K. Pregnancy in a rudimentary uterine horn: two case reports. Obstet Gynecol. 1969;34:805–8.

    CAS  PubMed  Google Scholar 

  96. Fore C, Parker T, Anderson E, et al. Urologic and genetic anomalies in patients with congenital absence of the vagina. Obstet Gynecol. 1975;46:410–6.

    CAS  PubMed  Google Scholar 

  97. Heinonen P. Unicornuate uterus and rudimentary horn. Fertil Steril. 1997;68:224–30.

    CAS  PubMed  Google Scholar 

  98. Morgan GR, Smith ML, et al. Uterus didelphys with unilateral haematocolpos ipsilateral renal agenesis and menses. J Reprod Med. 1987;32:47–58.

    CAS  PubMed  Google Scholar 

  99. Anderson J, et al. Uterus didelphia with left hematocolpos and ipsilateral renal agenesis. J Urol. 1982;127:550–3.

    CAS  PubMed  Google Scholar 

  100. Fedele S, Tozzi L, et al. Fertility in women with unicornuate uterus. BJOG. 1995;102:1007–9.

    CAS  Google Scholar 

  101. Kriplani S, Mittai S, Buckshee K, et al. Pre-rupture diagnosis and management of rudimentary horn in the first trimester. Eur J Obstet Gynecol Reprod Biol. 1995;58:203–5.

    CAS  PubMed  Google Scholar 

  102. Wahlen T. Pregnancy in non-communicating rudimentary uterine horn. Acta Obstet Gynecol Scand. 1972;51:155–60.

    CAS  PubMed  Google Scholar 

  103. Mavrelos D, Sawyer E, Helmy S, Holland TK, Ben-Nagi J, Jurkovic D. Ultrasound diagnosis of ectopic pregnancy in the non-communicating horn of a unicornuate uterus (cornual pregnancy). Ultrasound Obstet Gynecol. 2007;30(5):765–70.

    CAS  PubMed  Google Scholar 

  104. Jurkovic D, Gruboeck K, Tailor A, Nicolaides KH. Ultrasound screening for congenital uterine anomalies. Br J Obstet Gynaecol. 1997;1997(104):1320–1.

    Google Scholar 

  105. Nishi H, Funayama H, Fukumine N, Yagishita M, Nohira T, Suzuki Y, et al. Rupture of pregnant noncommunicating rudimentary uterine horn with fetal salvage: a case report. Arch Gynecol Obstet. 2003;268(3):224–6.

    PubMed  Google Scholar 

  106. Holden R, Hart P. First-trimester rudimentary horn pregnancy: prerupture ultrasound diagnosis. Obstet Gynecol. 1983;61(3 Suppl):56S–8S.

    Google Scholar 

  107. Hefny FT, Nambiar R, Bashir MO, et al. A rare case of first-trimester ruptured bicornuate uterus in a primigravida. Int J Surg Case Rep. 2015;14:98–100.

    PubMed  PubMed Central  Google Scholar 

  108. Salim R, Woelfer B, Backos M, Regan L, Jurkovic D. Reproducibility of three-dimensional ultrasound diagnosis of congenital uterine anomalies. Ultrasound Obstet Gynecol. 2003;21(6):578–82.

    CAS  PubMed  Google Scholar 

  109. Poujade O, Ducarme G, Luton D. Cornual heterotopic pregnancy: a case report. J Med Case Rep. 2009;3:7233.

    Google Scholar 

  110. Heinonen S, Pstynen P, et al. Reproductive performance of women with uterine anomalies. Acta Obstet Gynecol Scand. 1982;61:157–62.

    CAS  PubMed  Google Scholar 

  111. Nahum G. Rudimentary uterine horn pregnancy: case report on surviving twins delivered 8 days apart. J Reprod Med. 1997;42:525–32.

    CAS  PubMed  Google Scholar 

  112. Raga F, Bonilla-Musoles F, Blanes J, Osborne NG. Congenital Müllerian anomalies: diagnostic accuracy of three-dimensional ultrasound. Fertil Steril. 1996;65(3):523.

    Google Scholar 

  113. Jurkovic D, Geipel A, Gruboeck K, Jauniaux E, Natucci M, Campbell S. Three-dimensional ultrasound for the assessment of uterine anatomy and detection of congenital anomalies: a comparison with hysterosalpingography and two-dimensional sonography. Ultrasound Obstet Gynecol. 1995;5(4):233–7.

    CAS  PubMed  Google Scholar 

  114. Leyendecker JR, Gorengaut V, Brown JJ. MR imaging of maternal diseases of the abdomen and pelvis during pregnancy and the immediate postpartum period. Radiographics. 2004;24(5):1301–16.

    PubMed  Google Scholar 

  115. Falcone T, Gidwani G, Paraiso M, Beverly C, Goldberg J. Anatomical variation in the rudimentary horns of a unicornuate uterus: implications for laparoscopic surgery. Hum Reprod. 1997;12(2):263–5.

    CAS  PubMed  Google Scholar 

  116. Dicker D, Nitke S, Shoenfeld A, Fish B, Meizner I, Ben-Rafael Z. Laparoscopic management of rudimentary horn pregnancy. Hum Reprod. 1998;13(9):2643–4.

    CAS  PubMed  Google Scholar 

  117. Sönmezer M, Taskin S, Atabekoğlu C, Güngör M, Unlü C. Laparoscopic management of rudimentary uterine horn pregnancy: case report and literature review. J Soc Laparoendosc Surg. 2006;10(3):396–9.

    Google Scholar 

  118. Lazenby GB, Huang C, Rahall AM, Fogelson NS. Pregnancy termination via laparotomy in a woman with bicornuate uterus. Contraception. 2007;75(3):241–3.

    PubMed  Google Scholar 

  119. Panayotidis M, Leggott M, et al. Rupture of rudimentary uterine horn of a unicornuate uterus at 15 weeks’ gestation. J Obstet Gynaecol. 2004;24:323–4.

    CAS  PubMed  Google Scholar 

  120. Samuels TA, Awonuga A. Second-trimester rudimentary uterine horn pregnancy: rupture after labor induction with misoprostol. Obstet Gynecol. 2005;106(5 Pt 2):1160–2.

    Google Scholar 

  121. Shahid A, Olowu O, Kandasamy G, O’Donnell C, Odejinmi F. Laparoscopic management of a 16-week ruptured rudimentary horn pregnancy: a case and literature review. Arch Gynecol Obstet. 2010;282(2):121–5.

    PubMed  Google Scholar 

  122. Lata D, Agarwal S, Niyaz Z, et al. Ruptured rudimentary horn pregnancy misdiagnosed as ruptured pseudo aneurysm internal iliac artery. Int J Crit Illn Inj Sci. 2013;3:284–5.

    PubMed  PubMed Central  Google Scholar 

  123. Rathod SK, et al. A true cornual pregnancy with placenta percreta resulting in a viable fetus. Int J Appl Basic Med Res. 2015;5:203–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  124. Sharma D, Usha M, Gaikwad R, Sudha S. Laparoscopic resection of unruptured rudimentary horn pregnancy. Int J Reprod Contracept Obstet Gynecol. 2013;2(1):95.

    Google Scholar 

  125. Wang PH, Chao HT, Too LL, Yuan CC. Primary repair of cornual rupture occurring at 21 weeks gestation and successful pregnancy outcome. Hum Reprod. 1999;14(7):1894–5.

    CAS  PubMed  Google Scholar 

  126. Lee MH, Im SY, Kim MK, Shin SY, Park WI. Comparison of laparoscopic cornual resection and cornuotomy for interstitial pregnancy. J Minim Invasive Gynecol. 2017;24(3):397–401.

    PubMed  Google Scholar 

  127. Chen J, Huang D, Shi L, Zhang S. Prevention, diagnosis, and management of interstitial pregnancy: a review of the literature. Laparosc Endosc Robot Surg. 2019;2(1):12–7.

    Google Scholar 

  128. Moon HS, Choi YJ, Park YH, Kim SG. New simple endoscopic operations for interstitial pregnancies. Am J Obstet Gynecol. 2000;182(1):114–21.

    CAS  PubMed  Google Scholar 

  129. Afifi Y, Mahmud A, Fatma A. Hemostatic techniques for laparoscopic management of cornual pregnancy: double-impact devascularization technique. J Minim Invasive Gynecol. 2016;23(2):274–80.

    PubMed  Google Scholar 

  130. Gomel V, McComb P. Microsurgical transposition of the human fallopian tube and ovary with subsequent intrauterine pregnancy. Fertil Steril. 1985;43(5):804–8.

    CAS  PubMed  Google Scholar 

  131. Goldberg JM, Friedman CI. Microsurgical fallopian tube transposition with subsequent term pregnancy. Fertil Steril. 1988;50(4):660–1.

    CAS  PubMed  Google Scholar 

  132. Cutner A, Saridogan E, Hart R, Pandya P, Creighton S. Laparoscopic management of pregnancies occurring in non-communicating accessory uterine horns. Eur J Obstet Gynecol Reprod Biol. 2004;113(1):106–9.

    PubMed  Google Scholar 

  133. Walker A. Der Bau der Eihäute bei Graviditatis Abdominalis. Virch Arch Path Anat. 1887;197:72–99.

    Google Scholar 

  134. Hellman HJ, et al. Full term intra-abdominal pregnancy. Am J Surg. 1935;29:403–13.

    Google Scholar 

  135. Eisaman CE, et al. Abdominal pregnancy: report of a case with a full term living infant and recovery of the mother. JAMA. 1935;104:2175–6.

    Google Scholar 

  136. Strafford WD, et al. Abdominal pregnancy. Review of current management. Obstet Gynecol. 1977;50:548–52.

    CAS  PubMed  Google Scholar 

  137. Delke WP, Tawcer ML IV. Abdominal pregnancy: review of current management and addition of 10 cases. Obstet Gynecol. 1982;60:200–3.

    CAS  PubMed  Google Scholar 

  138. Atrash HK, Friede A, Hogue CJ. Abdominal pregnancy in the United States: frequency and maternal mortality. Obstet Gynecol. 1987;69:333–7.

    CAS  PubMed  Google Scholar 

  139. Maas DA, Slabber CF. Diagnosis and treatment of advanced extra-uterine pregnancy. S Afr Med J. 1975;49(4876081025):2007–10.

    CAS  PubMed  Google Scholar 

  140. Riethmuller D, Courtois L, Maillet R, Schaal JP. [Ectopic pregnancy management: cervical and abdominal pregnancies]. J Gynecol Obstet Biol Reprod (Paris). 2003;32(7 Suppl): S101–8.

    Google Scholar 

  141. Costa J, Bastert G, et al. Advanced abdominal pregnancy. Obstet Gynecol Surv. 1991;46:515–25.

    CAS  PubMed  Google Scholar 

  142. Beacham WC, Beacham DW, et al. Abdominal pregnancy at Charity Hospital in New Orleans. Am J Obstet Gynecol. 1962;84:1257–70.

    CAS  PubMed  Google Scholar 

  143. Stratford WD, et al. Abdominal pregnancy: review of current management. Obstet Gynecol. 1977;50:548–52.

    Google Scholar 

  144. Ombelet JV, Van Assche FA, et al. Advanced extrauterine pregnancy: description of 38 cases with literature survey. Obstet Gynecol Surv. 1988;43:386–97.

    CAS  PubMed  Google Scholar 

  145. Lastra JA, Jiménez Balderas EA. Abdominal pregnancy with fetal survival. A report of 2 cases. Ginecol Obstet Mex. 1993;61:348–50.

    Google Scholar 

  146. Yoder N, Tal R, Martin JR. Abdominal ectopic pregnancy after in vitro fertilization and single embryo transfer: a case report and systematic review. Reprod Biol Endocrinol. 2016;14(1):1–10.

    Google Scholar 

  147. Huang B, Hu D, Qian K, Ai J, Li Y, Jin L, et al. Is frozen embryo transfer cycle associated with a significantly lower incidence of ectopic pregnancy? An analysis of more than 30,000 cycles. Fertil Steril. 2014;102(5):1345–9.

    PubMed  Google Scholar 

  148. Decleer W, Osmanagaoglu K, Meganck G, Devroey P. Slightly lower incidence of ectopic pregnancies in frozen embryo transfer cycles versus fresh in vitro fertilization-embryo transfer cycles: a retrospective cohort study. Fertil Steril. 2014;101(1):162–5.

    PubMed  Google Scholar 

  149. Rombauts L, McMaster R, Motteram C, Fernando S. Risk of ectopic pregnancy is linked to endometrial thickness in a retrospective cohort study of 8120 assisted reproduction technology cycles. Hum Reprod. 2015;30(12):2846–52.

    CAS  PubMed  Google Scholar 

  150. Tutuncu E, Muhcu M, et al. Does previous Cesarean delivery increase the risk of ectopic pregnancy? Perinatal J. 2005;13:105–9.

    Google Scholar 

  151. Audain L, Brown WE, Smith DM, Clark JF. Cocaine use as a risk factor for abdominal pregnancy. J Natl Med Assoc. 1998;90(5):277–83.

    Google Scholar 

  152. Oehninger S, Kreiner D, Bass MJ, Rosenwaks Z. Abdominal pregnancy after in vitro fertilization and embryo transfer. Obstet Gynecol. 1988;72(3):499.

    CAS  PubMed  Google Scholar 

  153. Kalchman RM, et al. Interstitial pregnancy following homolateral salpingectomy: report of 2 cases and review of the literature. Am J Obstet Gynecol. 1966;96:1139–43.

    CAS  PubMed  Google Scholar 

  154. Woods E. Abdominal pregnancy at term with delivery of normal living child. Am J Obstet Gynecol. 1936;32:155–7.

    Google Scholar 

  155. Rahman MS, Al-Suleiman SA, Rahman J, Al-Sibai MH. Advanced abdominal pregnancy--observations in 10 cases. Obstet Gynecol. 1982;59(3):366–72.

    Google Scholar 

  156. Plewes W. Abdominal pregnancy complicated by appendicitis and bilateral pyosalpinx. Can Med Assoc J. 1937;37:172–3.

    CAS  PubMed  PubMed Central  Google Scholar 

  157. Storeide O, Veholmen M, Eide M, Bergsjø P, Sandvei R. The incidence of ectopic pregnancy in Hordaland County, Norway 1976-1993. Acta Obstet Gynecol Scand. 1997;76(4):345–9.

    Google Scholar 

  158. Jacobson D, et al. Heterotopic pregnancies and IVF. Fertil Steril. 1990;54:179–80.

    CAS  PubMed  Google Scholar 

  159. Bonfield J. A case of extrauterine pregnancy. Can Med Assoc J. 1935;33:308–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  160. Dündar L, Müngen E, et al. Heterotopic pregnancy: tubal ectopic pregnancy and monochorionic monoamniotic twin pregnancy: a case report. Perinatal J. 2006;14:96–100.

    Google Scholar 

  161. Bertrand G, le Ray C, Simard-Emond L, Dubois J, Leduc L. Imaging in the management of abdominal pregnancy: a case report and review of the literature. J Obstet Gynaecol Can. 2009;31(1):57–62.

    Google Scholar 

  162. Allibone GW, Fagan CJ, Porter SC. The sonographic features of intra-abdominal pregnancy. J Clin Ultrasound. 1981;9(7):383–7.

    CAS  PubMed  Google Scholar 

  163. Stanley EO III, et al. Sonographic findings in abdominal pregnancy. Am J Roentgenol. 1986;147:1043–6.

    CAS  Google Scholar 

  164. Yildizhan A, Adali F, et al. Primary abdominal ectopic pregnancy: a case report. Cases J. 2009;2:8485.

    PubMed  PubMed Central  Google Scholar 

  165. Meinert J. Advanced ectopic pregnancy including combined ectopic and intrauterine pregnancy. Geburtshilfe Frauenheikd. 1981;41:490–5.

    CAS  Google Scholar 

  166. Koo HS, Bae JY, Kang IS, Koong MK, Kim HO, Cha SH, et al. Laparoscopic management of early primary peritoneal pregnancy: a case report. Clin Exp Reprod Med. 2011;38(2):109–14.

    PubMed  PubMed Central  Google Scholar 

  167. Zinger M, Rosenfeld D. Failed treatment of abdominal pregnancy with methotrexate: a case report. J Reprod Med Obstet Gynecol. 2001;46(4):392–4.

    Google Scholar 

  168. Beddock R, Naepels P, Gondry C, Besserve P, Camier B, Boulanger JC, et al. [Diagnosis and current concepts of management of advanced abdominal pregnancy]. Gynecol Obstet Fertil. 2004;32(1):55–61.

    Google Scholar 

  169. Worley KC, Hnat MD, Cunningham FG. Advanced extrauterine pregnancy: diagnostic and therapeutic challenges. Am J Obstet Gynecol. 2008;198(3):297.e1.

    PubMed  Google Scholar 

  170. Martin JN Jr, McCaul JF 4th. Emergent management of abdominal pregnancy. Clin Obstet Gynecol. 1990;33(3):438–47.

    Google Scholar 

  171. Ang LP, Tan AC, Yeo SH. Abdominal pregnancy: a case report and literature review. Singap Med J. 2000;41(9):454–7.

    CAS  Google Scholar 

  172. Cardosi AC, Londono J, Hoffman MS, et al. Embolization for advanced abdominal pregnancy with a retained placenta. A case report. J Reprod Med. 2002;47:861–3.

    PubMed  Google Scholar 

  173. Rahaman J, Berkowitz R, Mitty H, Gaddipati S, Brown B, Nezhat F. Minimally invasive management of an advanced abdominal pregnancy. Obstet Gynecol. 2004;103(5 Pt 2):1064–8.

    Google Scholar 

  174. Kerr J, Mikhail M, et al. Preoperative transcatheter embolization of abdominal pregnancy: report of three cases. J Vasc Interv Radiol. 1993;4:733–5.

    CAS  PubMed  Google Scholar 

  175. Kivikoski AI, Martin C, Weyman P, Picus D, Giudice L. Angiographic arterial embolization to control hemorrhage in abdominal pregnancy: a case report. Obstet Gynecol. 1988;71(3 Pt 2):456–9.

    Google Scholar 

  176. Hreshchyshyn M, Naples J, Randall C. Amethopterin in abdominal pregnancy. Am J Obstet Gynecol. 1965;93(2):286–7.

    CAS  PubMed  Google Scholar 

  177. Ludwig M, Kaisi M, Bauer O, Diedrich K. The forgotten child - a case of heterotopic, intra-abdominal and intrauterine pregnancy carried to term. Hum Reprod. 1999;14(5):1372–4.

    CAS  PubMed  Google Scholar 

  178. Martin JN, Sessums JK, Martin RW, Pryor JA, Morrison JC. Abdominal pregnancy: current concepts of management. Obstet Gynecol. 1988;71:549–57.

    Google Scholar 

  179. Hreshchyshyn B, Loughran CH, et al. What is the actual present-day management of the placenta in late abdominal pregnancy. Analysis of 101 cases. Am J Obstet Gynecol. 1961;81:302–17.

    CAS  PubMed  Google Scholar 

  180. Ayinde OA, Aimakhu CO, Adeyanju OA, Omigbodun AO. Abdominal pregnancy at the University College Hospital, Ibadan: a ten-year review. Afr J Reprod Health. 2005;9(1):123–7.

    Google Scholar 

  181. Clark SA, et al. Advanced ectopic pregnancy. J Reprod Med. 1975;14:30–3.

    CAS  PubMed  Google Scholar 

  182. Dahab AA, Aburass R, Shawkat W, Babgi R, Essa O, Mujallid RH. Full-term extrauterine abdominal pregnancy: a case report. J Med Case Rep. 2011;5:531.

    Google Scholar 

  183. France JT, Jackson P. Maternal plasma and urinary hormone levels during and after a successful abdominal pregnancy. Br J Obstet Gynaecol. 1980;87(5):356–62.

    Google Scholar 

  184. Lurie S. The history of the diagnosis and treatment of ectopic pregnancy: a medical adventure. Eur J Obstet Gynecol Reprod Biol. 1992;43:1–7.

    CAS  PubMed  Google Scholar 

  185. Hallatt JG, Grove JA. Abdominal pregnancy: a study of twenty-one consecutive cases. Am J Obstet Gynecol. 1985;152(4):444–9.

    CAS  PubMed  Google Scholar 

  186. Bohiltea V, Tufan C, et al. Abdominal pregnancy - case presentation. J Med Life. 2015;8:49–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  187. St Clair DA, Fish SA, et al. Methotrexate in abdominal pregnancy. JAMA. 1969;208:529–31.

    Google Scholar 

  188. Lathrop GE, et al. Methotrexate in abdominal pregnancy. Report of a case. Obstet Gynecol. 1968;32:81–5.

    Google Scholar 

  189. Stevens C. Malformations and deformations in abdominal pregnancy. Am J Med Genet. 1993;47:1189–95.

    CAS  PubMed  Google Scholar 

  190. Tan SM, Wee JH, et al. The paediatric aspect of advanced abdominal pregnancy. J Obstet Gynaecol Br Commonw. 1969;76:1021–8.

    Google Scholar 

  191. Miller JM Jr, Higginbottom MC, Smith DW, et al. Compression-related defects from early amnion rupture: evidence for mechanical teratogenesis. J Pediatr. 1981;98:292–7.

    CAS  PubMed  Google Scholar 

  192. Cornell E, Lash A. Abdominal pregnancy. Int Abstr Surg. 1933;57:98–104.

    Google Scholar 

  193. Echols CM. Ectopic pregnancy: observations in one hundred and three cases seen in private practice. J Am Med Assoc. 1934;103(22):1686–9.

    Google Scholar 

  194. Barrett M. Abdominal pregnancy: report of five additional cases. Am J Obstet Gynecol. 1952;64(5):1061–72.

    CAS  PubMed  Google Scholar 

  195. Billington W, Goodchild R. Two unusual cases of abdominal extrauterine pregnancy. Br Med J. 1948;2(4582):787.

    CAS  PubMed  PubMed Central  Google Scholar 

  196. Serebriakova A, Kanshin N. [Abdominal pregnancy with implantation of fertilized egg into the liver]. Akush Ginekol (Moskva). 1952;5:90.

    Google Scholar 

  197. Murley A. Liver pregnancy. Lancet. 1956;267(6930):994–5.

    Google Scholar 

  198. Kirby NG. Primary hepatic pregnancy. Br Med J. 1969;1(5639):296.

    CAS  PubMed  PubMed Central  Google Scholar 

  199. Mear Y, Ekra J, Raoelison S. [A case of hepatic implantation pregnancy with a living infant]. Sem Hop. 1965;41(23):1430–3.

    Google Scholar 

  200. Luwuliza-Kirunda J. Primary hepatic pregnancy: case report. BJOG. 1978;85(4):311–3.

    CAS  Google Scholar 

  201. Garzon S, Raffaelli R, Montin U, Ghezzi F. Primary hepatic pregnancy: report of a case treated with laparoscopic approach and review of the literature. Fertil Steril. 2018;110(5):925–931.e1.

    PubMed  Google Scholar 

  202. Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X, et al. Diagnosis and management of primary hepatic pregnancy: literature review of 31 cases, vol. 298. Archives of Gynecology and Obstetrics; 2018. p. 235–42.

    Google Scholar 

  203. He S, Cheng Y, Zhang G, Qi H, Sun Q. Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature. Int J Clin Exp Pathol. 2019;12(12):4344.

    PubMed  PubMed Central  Google Scholar 

  204. Ali V, Lilja JF, Chuang AZ, Mogallapu RV, Sabonghy E. Incidence of perihepatic adhesions in ectopic gestation. Obstet Gynecol. 1998;92(6):995–8.

    CAS  PubMed  Google Scholar 

  205. Kitade M, Takeuchi H, Kikuchi I, Shimanuki H, Kumakiri J, Kinoshita K. A case of simultaneous tubal-splenic pregnancy after assisted reproductive technology. Fertil Steril. 2005;83(4):1042.

    PubMed  Google Scholar 

  206. Tenore JL. Ectopic pregnancy. Am Fam Physician. 2000;61(4):1080–8.

    Google Scholar 

  207. Ramphal S, Moodley J, Rajaruthnam D. Hepatic pregnancy managed conservatively. Trop Dr. 2010;40(2):121–2.

    CAS  Google Scholar 

  208. Zhang N, Yang L, Wang Y, Li X, Zhang C, Xu J. Primary hepatic ectopic pregnancy in a patient with polycystic ovary syndrome: a case report. Medicine. 2020;99(13):e19649.

    PubMed  PubMed Central  Google Scholar 

  209. Cai YY, Xiao EH, Shang QL, Xiao LZ. Ectopic pregnancy in the liver incidentally diagnosed by imaging: a case report. Exp Ther Med. 2017;14(1):373–6.

    PubMed  PubMed Central  Google Scholar 

  210. Antequera A, Babar Z, Balachandar C, Johal K, Sapundjieski M, Qandil N. Managing ruptured splenic ectopic pregnancy without splenectomy: case report and literature review. Reprod Sci. 2021;28:2323.

    CAS  PubMed  Google Scholar 

  211. Harris GJ, Jurf AS, Yuh WTC, Abu Yousef MM. Intrahepatic pregnancy: a unique opportunity for evaluation with sonography, computed tomography, and magnetic resonance imaging. JAMA. 1989;261(6):902–4.

    CAS  PubMed  Google Scholar 

  212. Shippey SH, Bhoola SM, Royek AB, Long ME. Diagnosis and management of hepatic ectopic pregnancy. Obstet Gynecol. 2007;109(2 Part 2 Suppl):544–6.

    Google Scholar 

  213. Wang C, Cheng L, Zhang Z, Yuan Z. Imaging diagnosis of hepatic ectopic pregnancy: a report of one case. Intractable Rare Dis Res. 2012;1(1):40–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  214. Sibetcheu Tchatou A, Tchounzou R, Mbuagbaw L, Mboudou ET. Successful medical treatment of a hepatic pregnancy: a case report. J Med Case Rep. 2017;11(1):70.

    CAS  PubMed  PubMed Central  Google Scholar 

  215. Ma J, Zhou C, Duan Z, Jiang Y. Successful management of primary hepatic pregnancy with selective hepatic artery embolization and intra-arterial methotrexate infusion. Int J Gynecol Obstet. 2013;122(1):78–9.

    CAS  Google Scholar 

  216. Brouard KJ, Howard BR, Dyer RA. Hepatic pregnancy suspected at term and successful delivery of a live neonate with placental attachment to the right lobe of the liver. Obstet Gynecol. 2015;126(1):207–10.

    PubMed  Google Scholar 

  217. Nichols C, Koong D, Faulkner K, Thompson G. A hepatic ectopic pregnancy treated with direct methotrexate injection. Aust N Z J Obstet Gynaecol. 1995;35(2):221–3.

    CAS  PubMed  Google Scholar 

  218. Chin PS, Wee HY, Chern BSM. Laparoscopic management of primary hepatic pregnancy: case reports. Aust N Z J Obstet Gynaecol. 2010;50(1):95–8.

    PubMed  Google Scholar 

  219. Astruc J. A treatise on the diseases of the women. London: T Cooper; 1767. p. 56–62.

    Google Scholar 

  220. Abel K. Ovarian apoplexy. Lancet. 1964;283(7325):136–7.

    Google Scholar 

  221. Helde M, Campbell J, Himaya A, Nuyens A, Cowley F, Hurteau G. Detection of unsuspected ovarian pregnancy by wedge resection. Can Med Assoc J. 1972;106(3):237.

    Google Scholar 

  222. Moulonguet-Doleris P. Contribution a l’etude de la grossesse ovarienne. Gynecologie. 1924;23:257–86.

    Google Scholar 

  223. Strother-Stewart C. Primary ovarian pregnancy. Br J Surg. 1953;40(164):622–3.

    Google Scholar 

  224. Baden WF, Heins O. Ovarian pregnancy: case report with discussion of controversial issues in the literature. Am J Obstet Gynecol. 1952;64(2):353–8.

    CAS  PubMed  Google Scholar 

  225. Grimes HG, Nosal R, Gallagher J. Ovarian pregnancy: a series of 24 cases. Obstet Gynecol. 1983;61(2):174–80.

    CAS  PubMed  Google Scholar 

  226. Cabero A, Laso E, Laín J, Mañas C, Escribano I, Calaf J. Increasing incidence of ovarian pregnancy. Eur J Obstet Gynecol. 1989;31(3):227–32.

    CAS  Google Scholar 

  227. Choi HJ, Im KS, Jung HJ, Lim KT, Mok JE, Kwon YS. Clinical analysis of ovarian pregnancy: a report of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2011;158(1):87–9.

    PubMed  Google Scholar 

  228. Odejinmi F, Rizzuto M, MacRae R, Olowu O, Hussain M. Diagnosis and laparoscopic management of 12 consecutive cases of ovarian pregnancy and review of literature. J Minim Invasive Gynecol. 2009;16(3):354–9.

    Google Scholar 

  229. Sandvei R, Sandstad E, Steier JA, Ulstein M. Ovarian pregnancy associated with the intra-uterine contraceptive device: a survey of two decades. Acta Obstet Gynecol Scand. 1987;66(2):137–41.

    Google Scholar 

  230. Bozza AT, Horwitz ST. Ovarian pregnancy with an intrauterine contraceptive device in situ: a case report. Am J Obstet Gynecol. 1973;117(2):285–6.

    CAS  PubMed  Google Scholar 

  231. Johnston B. Ovarian pregnancy in association with a Copper 7 intrauterine contraceptive device. BMJ Mil Health. 1987;133(2):94–5.

    Google Scholar 

  232. Robertson S. Ovarian pregnancy in association with a “Copper 7” intrauterine device. Aust N Z J Obstet Gynaecol. 1974;14(1):48–9.

    Google Scholar 

  233. Marcus SF, Brinsden PR. Analysis of the incidence and risk factors associated with ectopic pregnancy following in-vitro fertilization and embryo transfer. Hum Reprod. 1995;10(1):199–203.

    CAS  PubMed  Google Scholar 

  234. Berger B, Blechner J. Ovarian pregnancy associated with copper-7 intrauterine device. Obstet Gynecol. 1978;52(5):597–600.

    CAS  PubMed  Google Scholar 

  235. Grafenberg E. Die intrauterine methode de konzerplionsuerhiitung. In: Heine N, editor. Proceedings of the Third Congress World League for Sexual Reform. London: Keegan, Paul, Treach, Trulener; 1930.

    Google Scholar 

  236. Darwish D, Saafan S. Ovarian ectopic pregnancy with IUCD. Br Med J. 1975;4(5989):143.

    CAS  PubMed  PubMed Central  Google Scholar 

  237. Netland PA, Netland AT, Solomon MB, Kaiser JS. Ovarian pregnancy with a Copper-7 intrauterine device in situ. J Fam Pract. 1983;16(2):389–95.

    CAS  PubMed  Google Scholar 

  238. Lehfeldt H, Tietze C, Gorstein F. Ovarian pregnancy and the intrauterine device. Am J Obstet Gynecol. 1970;108(7):1005–9.

    CAS  PubMed  Google Scholar 

  239. Ulstein M, Sandvei R. Comparison of the risk of ectopic pregnancy with the use of IUD or minipill. Contracept Deliv Syst. 1980;1(4):365–8.

    CAS  PubMed  Google Scholar 

  240. Campbell J, Hacquebard S, Mitton D, Hurteau G, Bobra S, et al. Acute hemoperitoneum, IUD, and occult ovarian pregnancy. Obstet Gynecol. 1974;43(3):438–42.

    CAS  PubMed  Google Scholar 

  241. Lindblom B, Hamberger L, Wiqvist N. Differentiated contractile effects of prostaglandins E and F on the isolated circular and longitudinal smooth muscle of the human oviduct. Fertil Steril. 1978;30(5):553–9.

    Google Scholar 

  242. Sandvei R, Anker C, Wollen AL, Flood PR. Mast cells in the tubal wall in women using an intrauterine contraceptive device. BJOG. 1986;93(7):758–64.

    Google Scholar 

  243. Hueppe F. Die Bedingungen der Ovarial- und Abdominalschwangerschaft. Berlin: Gustav Lange; 1876.

    Google Scholar 

  244. Spiegelberg O. Zur Casuistik den Ovarial - Schwangenschaft. Arch f Gynäk. 1878;13:73.

    Google Scholar 

  245. Norris C. Primary ovarian pregnancy and the report of a case combined with intrauterine pregnancy. Surg Gynecol Obstet. 1909;9(2):123–31.

    Google Scholar 

  246. Stander H. Williams obstetrics. 8th ed. New York, NY: D. Appleton Century Company; 1941.

    Google Scholar 

  247. Moyers ED, Lack A. Primary ovarian pregnancy: case report. Am J Obstet Gynecol. 1958;76(3):518–22.

    PubMed  Google Scholar 

  248. Bazán-Ruiz S, Anchayhua-Cucchi J, Ruiz-Leud M, Castillo-Pulido P. [Complicated ovarian ectopic pregnancy in the second trimester of pregnancy: report of a case]. Ginecol Obstet Mex. 2015;83(8):494–8.

    Google Scholar 

  249. Avila-Vergara MA, Peña-Ayón AR, Guzmán-Gutiérrez LE, Valenzuela-Verduzco JE, Caballero-Rodríguez CB, Vadillo-Ortega F. [A second trimester ovarian ectopic pregnancy: a case report]. Ginecol Obstet Mex. 2015;83(11):728–34.

    Google Scholar 

  250. Elwell KE, Sailors JL, Denson PK, Hoffman B, Wai CY. Unruptured second-trimester ovarian pregnancy. J Obstet Gynaecol Res. 2015;41(9):1483–6.

    Google Scholar 

  251. Lee ML, Li BC, Robins D, Tillmanns TD. Live full-term ovarian ectopic pregnancy: a case report. J Reprod Med. 2014;59:607–10.

    PubMed  Google Scholar 

  252. Ribeiro K, el Shamy T, Miskry T. Ovarian ectopic pregnancy after in vitro fertilisation treated by laparoscopic excision with ovarian preservation. BMJ Case Rep. 2020;13(11):e236680.

    Google Scholar 

  253. Chetty M, Elson J. Treating non-tubal ectopic pregnancy. Best Pract Res Clin Obstet Gynaecol. 2009;23(4):529–38.

    Google Scholar 

  254. Comstock C, Huston K, Lee W. The ultrasonographic appearance of ovarian ectopic pregnancies. Obstet Gynecol. 2005;105(1):42–5.

    Google Scholar 

  255. di Luigi G, Patacchiola F, la Posta V, Bonitatibus A, Ruggeri G, Carta G. Early ovarian pregnancy diagnosed by ultrasound and successfully treated with multidose methotrexate. Clin Exp Obstet Gynecol. 2012;39(3):390–3.

    PubMed  Google Scholar 

  256. Pagidas K, Frishman GN. Nonsurgical management of primary ovarian pregnancy with transvaginal ultrasound-guided local administration of methotrexate. J Minim Invasive Gynecol. 2013;20(2):252–4.

    Google Scholar 

  257. Shamma FN, Schwartz LB. Primary ovarian pregnancy successfully treated with methotrexate. Am J Obstet Gynecol. 1992;167(5):1307–8.

    CAS  PubMed  Google Scholar 

  258. Chelmow D, Gates E, Penzias A. Laparoscopic diagnosis and methotrexate treatment of an ovarian pregnancy: a case report. Fertil Steril. 1994;62(4):879–81.

    CAS  PubMed  Google Scholar 

  259. Annunziata N, Malignino E, Zarcone R. Ovarian pregnancies treated with methotrexate. Panminerva Med. 1996;38(3):190–2.

    CAS  PubMed  Google Scholar 

  260. Juan YC, Wang PH, Chen CH, Ma PC, Liu WM. Successful treatment of ovarian pregnancy with laparoscopy-assisted local injection of etoposide. Fertil Steril. 2008;90(4):1200.e1–2.

    Google Scholar 

  261. Fouelifack FY, Fouogue JT, Fouedjio JH, Sando Z. Ovarian pregnancy: a case report in a resource-poor setting. Pan Afr Med J. 2013;16:143.

    PubMed  PubMed Central  Google Scholar 

  262. Ranaivoson HVR, Ranaivomanana VF, Nomenjanahary L, Andriamampionona TF, Randrianjafisamindrakotroka NS. [Ovarian pregnancy: about 3 cases and review of the literature]. Pan Afr Med J. 2016;25:128.

    Google Scholar 

  263. Gray CL, Ruffolo EH. Ovarian pregnancy associated with intrauterine contraceptive devices. Am J Obstet Gynecol. 1978;132(2):134–9.

    CAS  PubMed  Google Scholar 

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    Goran Augustin

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    Goran Augustin

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Augustin, G. (2023). Ruptured Ectopic Pregnancy. In: Acute Abdomen During Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-031-26021-6_9

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